Clinical burden comparison among elderly hospitalized patients for COVID-19, RSV, and influenza: a French study on inpatients HER (OMIP Study)

Study type

• Study topic:
  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Other
• Non-interventional study design, other:
  This is a retrospective observational study focusing on medical data from patients hospitalized for COVID-19, influenza, RSV or for secondary pneumococcal infection. ; These data will be collected from electronic medical records and local reimbursement data from 10 French hospitals.; The observational nature of the study is explained by the need to obtain data representative of real life. The retrospective aspect of the study is justified by our need to capture data close to the period of the COVID-19 pandemic.; This study plan will allow us to integrate both a descriptive analysis and a comparative analysis.; We will first compare morbidity and mortality, in terms of clinical and economic burden, associated with the different pathologies mentioned, as well as between two distinct seasons: from May 2022 to April 2023 and from May 2023 to April 2024. Next, we will describe the epidemiological profiles, estimate the incidence of affected patients and evaluate the performance of PMSI to detect RSV infection.

Population studied

• Short description of the study population:
  Cohort 1 will be composed of ≥60-year-old patients hospitalized due to COVID-19 infection.; Cohort 2 will be composed of ≥60-year-old patients hospitalized due to Influenza infection.; Cohort 3 will be composed of ≥60-year-old patients hospitalized due to RSV infection.; In each of the cohorts, the periods of inclusion will span from May 1, 2022, to April 30, 2023 (Period 1) and from May 1, 2023, to April 30, 2024 (Period 2).; Cohort 1-3 will consist of 1000 randomized patients from 10 health facilities.;
• Age groups:
  • Elderly (≥ 65 years)
• Special population of interest:
  Other
• Special population of interest, other:
  ≥60year old patients hospitalized due to : COVID-19 infection, Influenza infection or RSV infection. And ≥60year old patients hospitalized due to pneumococcal super-infection in a context of COVID-19, influenza, or RSV infection.
• Estimated number of subjects:
  6000

Study design details

• Study design:
  This is a retrospective observational study focusing on medical data from patients hospitalized for COVID-19, influenza, RSV or for secondary pneumococcal infection. These data will be collected from electronic medical records and local reimbursement data from 10 French hospitals.
• Main study objective:
  The main objective of this study is to compare the morbidity-mortality of elderly patients hospitalized with COVID-19 (cohort 1), influenza (cohort 2) or RSV infection (cohort 3), in a sample of 10 French hospitals over the period 1 (from May 1, 2022, to April 30, 2023) and the period 2 (from May 1, 2023, to April 30, 2024) by subgroup of interest and time period.