Study type

Study type

Non-interventional study
Non-interventional study

Scope of the study

Disease epidemiology

Non-interventional study design

Cohort
Population studied

Age groups

Children (2 to < 12 years)
Adolescents (12 to < 18 years)
Adults (18 to < 46 years)
Adults (46 to < 65 years)
Adults (65 to < 75 years)
Adults (75 to < 85 years)
Adults (85 years and over)

Estimated number of subjects

20000000
Study design details

Main study objective

To characterise patients with multiple myeloma(MM) diagnosed 2012-2022. Specific objectives are to describe demographic and clinical characteristics of patients with MM at the time of diagnosis, MM treatments and MM treatment sequences and to estimate survival of incident MM cases during the study.

Outcomes

Treatment/s initiated at index date, 1 to 30, 1 to 90 and/or 1 to 365 days post index date, and death.

Data analysis plan

Large-scale patient-level characterisation will be conducted. Age and sex at time of multiple myeloma diagnosis, medical history and medication use will be described. The number and % of patients receiving each of a pre-specified list of multiple myeloma treatments and treatment combinations will also be described. Additionally, treatment patterns and sequences over time will be described. Survival will be estimated as the probability of survival from any cause of death and will be reported using Kaplan-Meier plots. This analysis will be conducted only for databases with complete information on mortality. A minimum cell count of 5 will be used when reporting results, with any smaller counts obscured.
Documents
Results tables
English (4.08 MB - PDF)View document
Study, other information
English (1.49 MB - PDF)View document