A retrospective cohort study to investigate the initiation and persistence of dual antiplatelet treatment after acute coronary syndrome in a Finnish setting – THALIA

Study type

• Study topic:
  Disease /health condition

  Human medicinal product
• Study type:
  Non-interventional study
• Scope of the study:
  Drug utilisation
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Anatomical Therapeutic Chemical (ATC) code:
  (B01AC04) clopidogrel

  clopidogrel

  (B01AC22) prasugrel

  prasugrel

  (B01AC24) ticagrelor

  ticagrelor
• Medical condition to be studied:
  Angina unstable

  Acute myocardial infarction

Population studied

• Short description of the study population:
  Finnish adult patients hospitalized for unstable angina pectoris or acute MI alive at discharge in 2009-2013.; ; Inclusion Criteria; Study population consisted of patients discharged alive from Finnish hospitals following admission for unstable angina pectoris (ICD-10: I20.0) or myocardial infarction (ICD-10: I21) between 01 Jan 2009 and 15 Dec 2013.; ; Exclusion Criteria; Age less than 18 years at hospital discharge for acute coronary syndrome
• Age groups:
  • Adults (18 to < 46 years)
  • Adults (46 to < 65 years)
  • Adults (65 to < 75 years)
  • Adults (75 to < 85 years)
  • Adults (85 years and over)
• Special population of interest:
  Other
• Special population of interest, other:
  Angina pectoris patients
• Estimated number of subjects:
  190000

Study design details

• Main study objective:
  The main objective of this study is to characterize and describe the patients treated with DAPT vs. non-DAPT treated patients, and the switch patterns and discontinuation rates of DAPT treatments.
• Data analysis plan:
  Drug treatment patterns in the study populations will be described as:- Proportion of patients with OAP medication.- Proportion of patients treated with different OAPs (any OAP and specific OAPs) for 3 months, 6 months, 9 months or 12 months after index day.- Switch patterns of OAP medication.- Discontinuation rates and switch patterns of OAP medication within 12 months after index day.- Medication possession rate.The study patients will be characterized in terms of:- Age- Gender- Time spent in the hospital before discharge at index date- Prior cardiovascular history within five years before index date - Interventions associated with the index event - Cardiovascular morbidity during follow-up associated with prolongation, switch or discontinuation of DAPT treatment - Major co-morbidities - Other medications- Type of hospital- Calendar year