Influence of social deprivation on psychotropic drugs dispensing in adults: a large cross-sectional population-based study in France (ISDepPSY)

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Drug utilisation

Non-interventional study

• Non-interventional study design:
  Cross-sectional

Study drug and medical condition

• Anatomical Therapeutic Chemical (ATC) code:
  (N05) PSYCHOLEPTICS

  PSYCHOLEPTICS

  (N06A) ANTIDEPRESSANTS

  ANTIDEPRESSANTS

Population studied

• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  2574310

Study design details

• Main study objective:
  To assess correlation between the number of dispensing of anxiolytic and hypnotic drugs and social deprivation (EDI).
• Outcomes:
  Correlation between EDI and number of distinct anxiolytic and hypnotic drugs (ATC: N05) dispensing. Correlation between EDI and number of distinct antidepressant drugs (ATC: N06A) dispensing.Correlation between EDI and adequacy with guidelines regarding psychotropic drug dispensing patterns among patients being dispensed at least one psychotropic drug.
• Data analysis plan:
  - Descriptive analyses- Comparative analyses between groups with Chi2 for categorical variables, and Student’s T test or variances analyses.- p-value <0.05 will be considered as statistically significant- Univariate analyses (linear regression) of the association between the number of anxiolytic and hypnotic drugs dispensed and EDI (primary objective), then other covariates and EDI (secondary objectives), will be performed to obtain correlation coefficients. If the assumptions for linear regression are not met, logistic regression will be performed to obtain Odds Ratios.- Then, a multivariate analysis (linear regression, otherwise logistic regression), will be performed. Covariates known to be associated with psychotropic drug misuse in the literature, and those associated in the univariate analysis (p-value < 0.20) will be selected for inclusion in the multivariate model, and secondarily excluded by a backward stepwise procedure.

Documents

Study publications

Delpierre C, Fantin R, Chehoud H, Nicoules V, Bayle A, Souche A, Tanguy M, Vali…

Murcia M, Chastang JF, Niedhammer I. Educational inequalities in major depressi…

Sjöstedt C, Ohlsson H, Li X, Sundquist K. Socio-demographic factors and long-te…

Surault P. Mental health and social determinants. L'encephale. 2010 Jan 1;36(3 …

Ducros D, Nicoules V, Chehoud H, Bayle A, Souche A, Tanguy M, Valière JP, Cayla…