Study identification

EU PAS number

EUPAS23454

Study ID

23455

Official title and acronym

Longitudinal Analyses of Body Mass Index and Risk of Parkinson's Disease in 2 million people over 2 decades (BMI and Parkinson´s disease)

DARWIN EU® study

No

Study countries

Spain
United Kingdom

Study description

Previous research suggests that people who are overweight or obese may have a higher risk of developing Parkinson’s disease than people with normal weight, while other studies show no such association. The objective of this study is therefore to investigate the association between BMI and risk of Parkinson’s disease. A cohort will be derived from CPRD of people aged 40 years or older with a first BMI recording between 1992 and 2007. People with a prior record of Parkinson’s disease or dementia will be excluded. Incidence rates of Parkinson’s disease will be calculated for each BMI category using Poisson regression, adjusting for differences in patient characteristics and allowing for competing risks with a novel approach. This study will provide information from a very large number of people (2 million) with a sizeable amount of follow-up data in a representative sample. The findings will therefore provide important information to help clarify the relationship between BMI and Parkinson’s disease to inform preventative and therapeutic strategies for Parkinson’s disease.

Study status

Ongoing
Research institutions and networks

Institutions

OXON Epidemiology
Spain
United Kingdom
First published:
15/03/2024
Institution Laboratory/Research/Testing facility Non-Pharmaceutical company ENCePP partner
OXON Epidemiology
Spain
United Kingdom
First published:
15/03/2024
Institution Laboratory/Research/Testing facility Non-Pharmaceutical company ENCePP partner

Contact details

Nawab Qizilbash MBChB MRCP(UK) BSc MSc DPhil(Oxon.)

Primary lead investigator

Study timelines

Date when funding contract was signed

Planned:
Actual:

Study start date

Planned:
Actual:

Data analysis start date

Planned:
Actual:

Date of final study report

Planned:
Sources of funding
Other

More details on funding

No funding
Regulatory

Was the study required by a regulatory body?

No

Is the study required by a Risk Management Plan (RMP)?

Not applicable