The Association between Long-Acting Beta-Agonists and Prescribing of Oral Steroids for Asthma Exacerbations

Study type

• Study topic:
  Human medicinal product

  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Effectiveness study (incl. comparative)
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Study drug International non-proprietary name (INN) or common name:
  FORMOTEROL

  SALMETEROL

  BECLOMETASONE

  BUDESONIDE

  CICLESONIDE

  FLUTICASONE

  MOMETASONE
• Medical condition to be studied:
  Asthma

Population studied

• Short description of the study population:
  Patients older than 12 years with asthma diagnosis in the Clinical Practice Research Datalink (CPRD).
• Age groups:
  • Paediatric Population (< 18 years)

    • Adolescents (12 to < 18 years)
  • Adult and elderly population (≥18 years)

    • Adults (18 to < 65 years)

      • Adults (18 to < 46 years)
      • Adults (46 to < 65 years)
• Special population of interest:
  Other
• Special population of interest, other:
  Asthma patients
• Estimated number of subjects:
  51103

Study design details

• Main study objective:
  This study aimed to examine the association between inhaled LABA monotherapy, ICS monotherapy, and ICS/LABA combination therapy, and prescribing of short courses of oral corticosteroids for asthma exacerbations in individuals older than 12 years with asthma in the United Kingdom.
• Outcomes:
  Prescribing short courses of oral corticosteroids for asthma exacerbations.
• Data analysis plan:
  Multi-category exposure marginal structural models and time-varying exposure Cox regression analyses will be applied.