Association between the Use of Hydrochlorothiazide and the Risk of Skin Cancers: A Population-Based Retrospective Cohort Study in Taiwan

Study identification

• EU PAS number:
  EUPAS47664
• Study ID:
  47834
• Official title and acronym:
  Association between the Use of Hydrochlorothiazide and the Risk of Skin Cancers: A Population-Based Retrospective Cohort Study in Taiwan
• DARWIN EU® study:
  No
• Study countries:
  Taiwan
• Study description:
  This is a retrospective cohort study aimed to evaluate the risk of skin cancer among Asian patients exposed to hydrochlorothiazide for long-term use. The comparator groups would be the chronic user of other thiazide diuretics, non-thiazide diuretics, and other antihypertensive drugs. Also, we enrolled a general population from the database to serve as the background risk of skin cancer. By implementing the multivariable cox-proportional hazard model, we could evaluate the risk of skin cancer compared with a different active comparators.
• Study status:
  Planned

Research institutions and networks

Institutions

National Cheng Kung University (NCKU)

Study timelines

Date when funding contract was signed

Planned:01/11/2020

Study start date

Planned:01/08/2021

Data analysis start date

Planned:31/12/2021

Date of interim report, if expected

Planned:31/12/2021

Date of final study report

Planned:01/06/2022

Sources of funding

Pharmaceutical company and other private sector 

More details on funding

Sanofi-Aventis

Regulatory

• Was the study required by a regulatory body?:
  No
• Is the study required by a Risk Management Plan (RMP)?:
  Not applicable