Association between the Use of Hydrochlorothiazide and the Risk of Skin Cancers: A Population-Based Retrospective Cohort Study in Taiwan

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Assessment of risk minimisation measure implementation or effectiveness

  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Anatomical Therapeutic Chemical (ATC) code:
  (C03AA03) hydrochlorothiazide

  hydrochlorothiazide

Population studied

• Age groups:
  • Adults (18 to < 46 years)
  • Adults (46 to < 65 years)
  • Adults (65 to < 75 years)
  • Adults (75 to < 85 years)
  • Adults (85 years and over)
• Estimated number of subjects:
  2000000

Study design details

• Main study objective:
  The risk of non-melanoma skin cancer (NMSC) among patients received hydrochlorothiazide versus other antihypertensive agents.
• Outcomes:
  NMSC is divided into squamous cell carcinoma and basal cell carcinoma, Malignant melanoma
• Data analysis plan:
  The survival analysis was implanted by the Cox-proportional hazard model and Kaplan-Meier method. The crude and adjusted hazard ratio between drug exposure and skin cancer outcome were calculated by univariate regression model and multivariate regression, respectively. In the multivariate regression model, including the baseline covariates into the stepwise selection process to identify the appropriate variables.