Renal replacement therapy: The influence of citrate vs. acetate buffering component on indoxyl sulfate elimination during bicarbonate dialysis

Study identification

• EU PAS number:
  EUPAS23714
• Study ID:
  23715
• Official title and acronym:
  Renal replacement therapy: The influence of citrate vs. acetate buffering component on indoxyl sulfate elimination during bicarbonate dialysis
• DARWIN EU® study:
  No
• Study countries:
  Czechia
• Study description:
  A monocentric, prospective, open cohort study will be performed in 43 male patients from a single hemodialysis center undergoing chronic renal replacement therapy. The aim is to determine the influence of acetate vs. citrate buffered dialysis fluids in hemodialysis (HD) and post-dilution hemodiafiltration (HDF) settings on the elimination of indoxyl sulfate. Also, additional factors potentially influencing the serum concentration of indoxyl sulfate will be evaluated.
• Study status:
  Planned

Research institutions and networks

Institutions

University Hospital Hradec Králové

Department of Clinical Biochemistry

Study timelines

Date when funding contract was signed

Planned: 02/05/2017

Actual: 02/05/2017

Study start date

Planned: 01/09/2017

Date of final study report

Planned: 02/07/2018

Sources of funding

Other

More details on funding

Ministry of Health of the Czech Republic grant DRO

Regulatory

• Was the study required by a regulatory body?:
  No
• Is the study required by a Risk Management Plan (RMP)?:
  Not applicable