Renal replacement therapy: The influence of citrate vs. acetate buffering component on indoxyl sulfate elimination during bicarbonate dialysis

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Assessment of risk minimisation measure implementation or effectiveness

  Effectiveness study (incl. comparative)

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Additional medical condition(s):
  Renal replacement therapy

Population studied

• Age groups:
  • Adults (18 to < 46 years)
  • Adults (46 to < 65 years)
  • Adults (65 to < 75 years)
• Special population of interest:
  Renal impaired
• Estimated number of subjects:
  45

Study design details

• Main study objective:
  The aim of this study was to determine the influence of acetate vs. citrate buffered dialysis fluids in hemodialysis (HD) and post-dilution hemodiafiltration (HDF) settings on the elimination of indoxyl sulfate.
• Outcomes:
  Elimination of indoxyl sulfate estimated from its serum concentrations.
• Data analysis plan:
  All statistical analyses will be performed using the SigmaStat software version 3.1. (Systat Software Inc. US).