Economic Burden Associated With Nintedanib Non-adherence Among Medicare Beneficiaries With IPF

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Drug utilisation

  Healthcare resource utilisation
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Medicinal product name:
  OFEV
• Study drug International non-proprietary name (INN) or common name:
  NINTEDANIB

Population studied

• Short description of the study population:
  Community-dwelling Medicare beneficiaries with IPF who initiate treatment with nintedanib.

Study design details

• Study design:
  This is a non-interventional, retrospective cohort study.
• Main study objective:
  1) Quantify the association between nintedanib adherence trajectory group (as measured from a GBTM) and health care resource use, with a focus on inpatient hospitalization, among patients with IPF. ; 2) Quantify the association between a patient’s nintedanib adherence trajectory group (as measured from a GBTM) and their medical costs among patients with IPF.
• Comparators:
  High adherers group
• Outcomes:
  The primary outcome was total all cause medical costs, which was calculated as the sum of total amounts paid (by payers and patients) for all medical services. Secondary outcomes were total IPF-related medical costs, which was calculated as the sum of total amounts paid (by payers and patients) for all medical services for an IPF-related reason (at least one IPF diagnosis code), all-cause inpatient hospitalization, and IPF-related inpatient hospitalization.
• Summary results:
  Adherence to nintedanib was associated with all-cause and, to a lesser extent, IPF-related hospitalizations and medical costs during the year adherence was measured. In the year after adherence was measured, patients in the delayed-poor adherence group had higher all-cause hospitalizations and medical costs. Further research is needed to unpack the mechanisms underlying these associations.