Bias after censoring concomitant users of test- and control medication when investigating long-term survival outcomes in observational studies of medication effects

Study type

• Study topic:
  Other
• Study topic, other:
  Methodology
• Study type:
  Not applicable
• Scope of the study:
  Method development or testing
• If ‘Not applicable’, further details on the study type:
  Simulation study

Non-interventional study

No information provided.

Study drug and medical condition

• Anatomical Therapeutic Chemical (ATC) code:
  (A10BK) Sodium-glucose co-transporter 2 (SGLT2) inhibitors

  Sodium-glucose co-transporter 2 (SGLT2) inhibitors

  (A10BH) Dipeptidyl peptidase 4 (DPP-4) inhibitors

  Dipeptidyl peptidase 4 (DPP-4) inhibitors
• Medical condition to be studied:
  Colorectal cancer

Population studied

No information provided.

Study design details

• Main study objective:
  This simulation study aims to compare methods aiming to mitigate the bias from censoring concomitant users, namely variations of the landmarking method and inverse-probability-of-censoring weighting and a combination thereof.