DARWIN EU® - Capturing suicidality and depression related variables in databases

Study type

• Study topic:
  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

  Feasibility analysis
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

Population studied

• Short description of the study population:
  For objective 1 and 2c, the general population will constitute the study population: ; Inclusion criteria ; • Minimum 365 days of available history before index date (except for hospital data sources) ; • Aged ≥10 years of age. This age cutoff is based on the World Health Organisation (WHO) definition for adolescence (age 10 to 19), since we do not expect relevant results in lower age groups.[3] ; For objective 2a, 2b. and 3: ; Inclusion criteria; • Minimum 365 days of available history before index date (except for hospital data sources) ; • Aged ≥10 years of age ; • Condition or observation of completed suicide, suicide-related events (suicide attempt, suicide ideation, or self-harm), or depression

Study design details

• Study design:
  The retrospective cohort study will comprise of: ; • A descriptive epidemiology study including the general population will be conducted to address objective 1 and 2c. ; • A descriptive study including individuals with the events of interest will be conducted to address objective 2a, 2b, and 3.
• Main study objective:
  To estimate the incidence and prevalence of individuals with a record of suicide, suicide-related ; events, depression, healthcare utilisation, symptom measurement data, procedures, and ; depression remission within the DARWIN EU® network. ; 2. To characterise reporting of suicide, suicide-related events, depression, symptom measurement, ; healthcare utilisation, and resolution reporting within the DARWIN EU® network in terms of: ; a) Mean and median of number of event reporting per individual within the study period. ; b) The mean cumulative function of event recording ; c) Describe the values of depression symptom measurement data. ; 3. To describe the characteristics of individuals with records of suicide, suicide-related events, and ; depression in terms of demographic characteristics, concomitant medications, comorbidities, ; procedures, and lifestyle factors.
• Setting:
  This study will be conducted using routinely collected data from 23 data sources in the DARWIN EU® network of data partners from 14 European countries, of which 12 EU member states. All data were a priori mapped to the OMOP CDM.