DARWIN EU® - Neonatal seizures: Incidence, prevalence, patient characterisation, and treatments in European countries

Study type

• Study type:
  Non-interventional study

Study design details

• Main study objective:
  1. To estimate the incidence and prevalence of seizures in neonates.; 2. To characterise patients’ demographic and clinical profile at the time of diagnosis, including:; - sex ; - age at diagnosis ; - gestational age; - weight at birth ; - Symptoms; - diagnostic tools (EEG, Video EEG, etc.); - comorbidities/concurrent conditions, including those presenting a high risk for seizure development hypoxic-ischemic encephalopathy, stroke or haemorrhage, infections, cortical malformations, errors of metabolism (acute and inborn), and genetic aetiologies.; 3. To characterise treatments received for the primary diagnosis of seizures in neonates, including standard of care, treatment pattern and duration of treatment.; 4. To describe short, mid and long-term outcomes (including survival, related diagnosed conditions such as neurodevelopmental, neurological [e.g. epilepsies, cerebral palsy]) at 1 month of discharge, 2 years of age and 6-7 years of age.