DARWIN EU® – Prevalence of selected cancers

Study type

• Study topic:
  Disease /health condition
• Study topic, other:
  Cancers
• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

Population studied

• Short description of the study population:
  All individuals in the database during the study period will be eligible for inclusion in the study. No prior history requirement will be applied in the primary analysis.
• Age groups:
  • In utero
  • Paediatric Population (< 18 years)

    • Neonate

      • Preterm newborn infants (0 – 27 days)
      • Term newborn infants (0 – 27 days)
    • Infants and toddlers (28 days – 23 months)
    • Children (2 to < 12 years)
    • Adolescents (12 to < 18 years)
  • Adult and elderly population (≥18 years)

    • Adults (18 to < 65 years)

      • Adults (18 to < 46 years)
      • Adults (46 to < 65 years)
    • Elderly (≥ 65 years)

      • Adults (65 to < 75 years)
      • Adults (75 to < 85 years)
      • Adults (85 years and over)

Study design details

• Study design:
  A cohort study will be conducted using routinely collected health data from 5 databases from 5 countries across Europe. This will consist of a descriptive epidemiological study providing point prevalence estimates of selected cancers in each participating database.
• Main study objective:
  The primary aim of this study is to estimate the point prevalence of rare blood cancers, pancreatic cancer, and soft tissue sarcoma across selected databases in Europe. ; The secondary aim of this study is to compare the prevalence of selected cancers included in the primary aim of the study, using denominator data available within the data source versus denominator data obtained from external sources.
• Outcomes:
  • Rare blood cancers: ; o Acute lymphocytic leukaemia (ALL) ; o Acute myeloid leukaemia (AML) ; o Chronic lymphocytic leukaemia (CLL) ; o Diffuse large B-Cell Lymphoma (DLBCL) ; o Follicular lymphoma ; o Multiple myeloma ; • Pancreatic cancer ; • Soft tissue sarcoma