Phenotyping Asthma Exacerbations in primary care: an electronic medical record study (PHASE)

Study identification

• EU PAS number:
  EUPAS1000000566
• Study ID:
  1000000566
• Official title and acronym:
  Phenotyping Asthma Exacerbations in primary care: an electronic medical record study (PHASE)
• DARWIN EU® study:
  No
• Study countries:
  United Kingdom
• Study description:
  The study is a historical, longitudinal, descriptive cohort study using patients’ electronic medical records (EMR) extracted from general practices from the Optimum Patient Care Research Database (OPCRD).; ; The primary aim of the study is to investigate whether blood eosinophil count (BEC) measured at stable state and/or exacerbation can discriminate between different exacerbation phenotypes and different clinical responses to oral corticosteroid and/or antibiotic treatment at exacerbation in primary care. ; ; The secondary aim of the study is to assess if low-BEC exacerbations predominate in winter, are more likely to be diagnostically labelled as infective by the clinician, and more frequently treated with oral antibiotics.;
• Study status:
  Planned

Research institutions and networks

Institutions

Nuffield Department of Medicine, University of Oxford

Optimum Patient Care (OPC)

United Kingdom

Study timelines

Date when funding contract was signed

Planned:30/05/2025

Study start date

Planned:07/07/2025

Date of final study report

Planned:07/12/2026

Sources of funding

Non-for-profit organisation (e.g. charity)

Regulatory

• Was the study required by a regulatory body?:
  No
• Is the study required by a Risk Management Plan (RMP)?:
  Not applicable