Study type

Study topic

Disease /health condition

Study type

Non-interventional study

Scope of the study

Disease epidemiology

Data collection methods

Secondary use of data
Non-interventional study

Non-interventional study design

Cohort
Study drug and medical condition

Medical condition to be studied

Hypertrophic cardiomyopathy

Additional medical condition(s)

Obstructive Hypertrophic cardiomyopathy
Population studied

Short description of the study population

The study population will include all individuals with a first diagnosis of HCM or oHCM (i.e., index date) identified in the database during the study period and with at least one year of medical history.
Study design details

Study design

The study will consist of a retrospective cohort design including patients with a first diagnosis of HCM or oHCM.

Main study objective

1. To estimate the annual prevalence of clinically apparent HCM and oHCM in Europe, overall and stratified by age and sex.

2. To characterise patients newly diagnosed with HCM and oHCM in terms of demographics, selected HCM-related clinical measurements, and comorbidities existing before, at the time of, and after a first HCM diagnosis.

3. To describe the frequency of selected HCM-related treatments, including medications, medical devices, and procedures before, at the time of, and after a first HCM diagnosis.

Setting

This study will be conducted using routinely collected health data from six databases in 6 European countries. All databases were previously mapped to the OMOP CDM.
Data sources:
1. Clinical Practice Research Datalink (CPRD) GOLD, United Kingdom (UK)
2. Danish Data Health Registries (DK-DHR), Denmark
3. InGef Research Database (InGef), Germany
4. Sistema d’Informació per al Desenvolupament de la Investigació en Atenció Primària (SIDIAP), Spain
5. Croatian National Public Health Information System (NAJS), Croatia
6. Norwegian Linked Health Registry data (NLHR), Norway