Exploring mediation through major bleeding between direct oral anticoagulants and cardiovascular events (MB mediation in CV RWE)

Data sources

• Data source(s), other:
  - Merative™ MarketScan® Commercial Claims and Encounters Database; - Merative™ MarketScan® Medicare Supplemental and Coordination of Benefits Database; - Optum® de-identified Electronic Health Record Dataset; - Optum’s de-identified Clinformatics® Data Mart Database; - IQVIA™ Adjudicated Health Plan Claims Data;
• Data sources (types):
  Administrative healthcare records (e.g., claims)

  Electronic healthcare records (EHR)

Use of a Common Data Model (CDM)

• CDM mapping:
  Yes

CDM Mappings

• CDM name:
  OMOP
• CDM website:
  https://www.ohdsi.org/Data-standardization/

• CDM version:
  5.4

Data quality specifications

• Check conformance:
  Yes
• Check completeness:
  Yes
• Check stability:
  Yes
• Check logical consistency:
  Yes

Data characterisation

• Data characterisation conducted:
  Yes
• Data characterisation moment:
  after extract-transform-load to a common data model
• Data characterisation details:
  The DatabaseDiagnostics package (Blacketer, 2023) was used to select those databases that include the required data elements for the estimation questions. Protocol section 10.4.3.