Effectiveness and impact of a 2-component acellular pertussis vaccine as a preschool booster in Finland – A register-based study (PER000108)

Study type

• Study topic:
  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

  Effectiveness study (incl. comparative)
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

  Other
• Non-interventional study design, other:
  Before-after comparison

Study drug and medical condition

• Name of medicine, other:
  Pertussis vaccine
• Medical condition to be studied:
  Pertussis

  Pertussis immunisation

Population studied

• Short description of the study population:
  Children less than 14 years of age in Finland 1995-2019, based on nationwide registers and population data
• Estimated number of subjects:
  2500000

Study design details

• Study design:
  Cohort study for estimating effectiveness, before-after comparison to compare different vaccination programs, descriptive epidemiology
• Main study objective:
  To evaluate the direct effectiveness of a 2-component acellular pertussis (2aP) vaccine administered as a preschool booster at 4 years of age against laboratory-confirmed pertussis during a follow-up of 5 years.; ;