DARWIN EU® Monitoring prescription of essential medicines administered in ICU

Study type

• Study topic:
  Human medicinal product
• Study type:
  Non-interventional study
• Scope of the study:
  Drug utilisation
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

No information provided.

Population studied

• Short description of the study population:
  Population-level drug utilisation: Population-level drug utilisation study included all patients being ; hospitalised in the respective databases in the period between 1st of January 2015 and 31st of December 2023 ; (or the latest date of data availability of respective database, whatever comes first). ; Patient-level drug utilisation: Patient-level drug utilisation study included hospitalised patients who were ; initiating treatment with selected prespecified medication categorised by ICU admission (yes/no) at the time ; of treatment initiation, in the period between 1st of January 2015 and 31st of December 2023 (or the latest ; date of data availability of respective database, whatever comes first).

Study design details

• Study design:
  • Population-level cohort study (Objective 1, Population-level drug utilisation study of selected medicines of importance for public health emergencies, specifically used in hospital/ICU). ; • New drug user cohort (Objective 2 and Objective 3)
• Main study objective:
  1. To estimate annual rate of prescription of selected medicines in a cohort of patients being hospitalised, stratified by ICU admission (yes/no). ; 2. To characterize the two cohorts of hospitalised patients (ICU admission (yes/no)) who initiated treatment with drug of interest in terms of demographics, presence of COVID-19 infection (yes/no), and use of mechanical ventilation (yes/no). ; 3. To determine the dose at treatment initiation and duration of treatment with selected medications in the cohort of hospitalised patients being treated with drug of interest, stratified by ICU admission (yes/no) and mechanical ventilation (yes/no). Optionally, consumption of the specified drugs at hospital level may be provided.
• Setting:
  Inpatient setting
• Summary results:
  CONCLUSION ; This study provides critical insights into the usage patterns of key medicines during public health emergencies, highlighting differences in ICU and non-ICU settings. The detailed data, including demographic characteristics, prescription rates, and treatment durations, offer valuable information for healthcare planning and resource and medicine allocation.