DARWIN EU® Comparing direct and indirect methods to estimate prevalence of chronic diseases using real-world data

Study type

• Study topic:
  Disease /health condition
• Study type:
  Non-interventional study

Study drug and medical condition

• Medical condition to be studied:
  Cystic fibrosis

  Haemophilia

  Pulmonary arterial hypertension

  Pancreatic carcinoma

  Sickle cell disease

Population studied

• Age groups:
  Paediatric Population (< 18 years)

  Preterm newborn infants (0 – 27 days)

  Term newborn infants (0 – 27 days)

  Infants and toddlers (28 days – 23 months)

  Children (2 to < 12 years)

  Adolescents (12 to < 18 years)

  Adult and elderly population (≥18 years)

  Adults (18 to < 65 years)

  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Elderly (≥ 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)

Study design details

• Study design:
  A retrospective cohort design to estimate disease point prevalence and incidence. A retrospective cohort design to estimate median survival as a proxy for disease duration. Data from three databases with routinely-collected electronic healthcare records of general practices will be used.
• Main study objective:
  The objective of this study is to compare direct and indirect estimations of prevalence of some rare, chronic diseases.