Exposure to ACEi, ARB and statin drugs among women of child-bearing age in Denmark

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Assessment of risk minimisation measure implementation or effectiveness

  Drug utilisation

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Anatomical Therapeutic Chemical (ATC) code:
  (C09C) ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN

  ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN

  (C10AA) HMG CoA reductase inhibitors

  HMG CoA reductase inhibitors

  (C09A) ACE INHIBITORS, PLAIN

  ACE INHIBITORS, PLAIN

Population studied

• Short description of the study population:
  National population
• Age groups:
  • Adults (18 to < 46 years)
  • Adults (46 to < 65 years)
• Estimated number of subjects:
  90000

Study design details

• Main study objective:
  To examine prescribing of RAS-acting drugs and statins among women of child-bearing age in Denmark
• Outcomes:
  ACEi, ARB and statin prescribing to women of child-bearing age, categorized in age-bands, 1997-2021 compared with prescribing to age-matched men; first-time prescriptions; continuity of prescriptions after initiation; ceasing; switching • Concomitant prescription of contraception among women of child-bearing age
• Data analysis plan:
  Descriptive statistics; Comparative prescription / switching / cessation across age groups and sex; Data to be reported as per STROBE and RECORD guidelines for observational studies using routinely collected health data