The UK nationwide cardiorespiratory impact of the COVID-19 pandemic

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Medical condition to be studied:
  Chronic obstructive pulmonary disease

  Myocardial infarction

Population studied

• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  509260

Study design details

• Main study objective:
  To describe the cardiorespiratory impact of the COVID-19 pandemic in the UK.
• Outcomes:
  COPD exacerbation, with those requiring hospitalization being described separately Myocardial infarction Death
• Data analysis plan:
  The monthly incidence rates of each outcome will be calculated separately for every month during the study period. The incidence rates will be described and visualized using histograms. Gross trends in incidence rates will be identified visually, specifically those before, during, and after the COVID-19 pandemic. The COVID-19 pandemic period will be defined using landmark dates in the UK’s anti-pandemic measures, with March 2020 (when the national lockdown started) being the start of the COVID-19 pandemic period, and March 2022 (when all anti-pandemic restrictions were lifted) being the end.