Prevalence of primary and secondary arterial hypertension in children and treatment with angiotensin II receptor blockers

Study type

• Study topic:
  Human medicinal product

  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Drug utilisation
• Data collection methods:
  Secondary data collection

Non-interventional study

• Non-interventional study design:
  Cohort

  Cross-sectional

Study drug and medical condition

• Anatomical Therapeutic Chemical (ATC) code:
  (C09D) ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
• Medical condition to be studied:
  Hypertension

Population studied

• Short description of the study population:
  The study involved children aged 2-17 years with arterial hypertension from January 2016 to June 2021 in the IQIVA™ Disease Analyzer France and Germany databases, and from January 1990 to May 2021 for IMRD (UK), including those registered or treated by general practioners and children treated by paediatricians in Germany, as pediatricians are part of primary care.
• Age groups:
  Children (2 to < 12 years)

  Adolescents (12 to < 18 years)
• Special population of interest:
  Other
• Special population of interest, other:
  Patients with arterial hypertension
• Estimated number of subjects:
  14000

Study design details

• Main study objective:
  The objective of this study was to estimate the number of children with arterial hypertension by age group and gender, and describe risk factors for primary hypertension or potential causes of secondary hypertension, estimate the yearly prevalence of arterial hypertension in children and the yearly proportion of children with arterial hypertension treated with ARBs by age group.
• Data analysis plan:
  A descriptive analysis of risk factors for arterial hypertension was carried in children 2-17 years with arterial hypertension during the study period (2016-2019). The yearly prevalence of arterial hypertension during the study period was calculated in children 2-17 years that were observable for at least one day during the year. Children with arterial hypertension during the year or with a history of arterial hypertension were included in the numerator, and the prevalence was the number of children in the numerator per 100,000 children observed for a year. Among yearly prevalent children with arterial hypertension, the proportion of children that also had a prescription for an ARB during the year was calculated. the yearly total number of children 2-17 years with an ARB prescription was identified, and among these children the proportion of children with a diagnosis of arterial hypertension during the year or earlier was calculated.

Documents

Study results

Arterial hypertension and ARBs use in children - Study report_for publication_CLEAN