PhEnotypic Characteristics, coMorBidities and response to thErapeutic inteRventions associated with non-type 2 asthma (EMBER)

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Cross-sectional

Study drug and medical condition

• Medical condition to be studied:
  Asthma

Population studied

• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  11000

Study design details

• Main study objective:
  To describe distributions of biomarkers for patients with severe asthma, identify patients displaying evidence of non-T2 phenotype, and assess how patients with T2 and non-T2 phenotypes respond to therapeutic interventions. We additionally aim to investigate disease burden through considering comorbid diseases
• Outcomes:
  Phenotypes of asthma patients based on biomarker measures, treatment responsiveness, exacerbation rates, Lung function, hospitalisations
• Data analysis plan:
  Cluster analysis will be used to identify phenotypes Poisson regression and Cox PH models will be used to analyse treatment responsiveness according to phenotype Chi-square, ANOVA, and t-tests will be used as tests of association Linear and logistic regression will be used to identify differences between groups