Global burden of hip fractures – trends in incidence, post-fracture treatment, and mortality; a multicountry, observational study (20190532)

Study type

• Study topic:
  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

  Other
• Non-interventional study design, other:
  Retrospective study

Study drug and medical condition

• Medical condition to be studied:
  Hip fracture

Population studied

• Short description of the study population:
  Patients hospitalized with hip fracture aged 50 years and older identified from 1st January 2005 to 31st December 2018.; Inclusion criteria: ; o aged 50 years or above ; o hospitalized due to hip fracture during the study period between 1st January 2005 and 31st December 2018; ; Exclusion criteria: ; o diagnosis of hip fracture within 12 months before the initial fracture; o missing sex or age; o less than 12 months in the data source before the initial hip fracture
• Age groups:
  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Special population of interest:
  Other
• Special population of interest, other:
  Patients with hip fracture
• Estimated number of subjects:
  3000000

Study design details

• Main study objective:
  To characterize hip fractures by year among men and women aged 50 years and above within multiple countries.
• Outcomes:
  To estimate the annual incidences of hip fracture. • To estimate the proportion of patient having use of a pharmacological treatment for fracture prevention within 12 months following their initial hip fracture by year. • To estimate the mortality rate within 12 months following patients’ initially hip fracture by year.
• Data analysis plan:
  The primary outcome will be calculated as the sum of hip fracture episodes in the year divided by the population at-risk in the year. A linear regression model will be used to test for time trends in the annual incidence proportion. Two-tailed P<0.05 will be considered statistically significant. For the 1st secondary outcome, the Kaplan-Meier method will be used to estimate the treatment proportion within 3, 6 & 12 months of fracture and 95% confidence intervals (CI), censoring patients on another hip fracture episode, 12 months, death, loss to follow-up, 31st December 2018 or the end of data available in a database, whichever earliest. For the 2nd secondary outcome, rate per calendar year of initial hip fracture will be calculated as the sum of patients who died of any cause during the 12-month follow-up period divided by the sum of patients with an initial hip fracture.

Documents

Study results

20190532 ORSR abstract_Redacted