Study type

Study type

Non-interventional study

Scope of the study

Disease epidemiology
Drug utilisation
Non-interventional study

Non-interventional study design

Cohort
Study drug and medical condition

Medical condition to be studied

Urinary tract infection
Population studied

Age groups

Adults (18 to < 46 years)
Adults (46 to < 65 years)
Adults (65 to < 75 years)
Adults (75 to < 85 years)
Adults (85 years and over)

Special population of interest

Hepatic impaired
Immunocompromised
Pregnant women
Renal impaired

Estimated number of subjects

1500000
Study design details

Main study objective

- To know the epidemiology of the different types of UTI in Catalonia and their diagnostic and therapeutic management. - To evaluate the correlation between the total consumption and type of antibiotics for recurrent UTI with the presence and severity of infectious complications of urological origin (pyelonephritis and sepsis), and two potentially serious infections (pneumonia and COVID-19

Data analysis plan

Descriptive statistics will be carried out on the results obtained. Quantitative variables will be described as mean and standard deviation, while categorical variables will be described as the proportion of exposed and unexposed individuals. Univariate tests will be obtained from Student's t-test and the chi-square test as appropriate. For the primary outcome, marginal structural models will be fitted to estimate causal effects by correcting for confounding. Inverse probability weights will be estimated as a function of propensity score using age and socioeconomic deprivation score. The inverse probability weights will be used in the marginal structural model to estimate the odds ratio and confidence intervals purchasing the prevalence of each outcome among individuals exposed to antibiotics versus those not exposed to antimicrobials.