Hearing loss and risk of major osteoporotic fracture: a population-based cohort study in the United Kingdom (20200418)

Study type

• Study topic:
  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Assessment of risk minimisation measure implementation or effectiveness
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Medical condition to be studied:
  Osteoporotic fracture

  Deafness

Population studied

• Short description of the study population:
  The study population included patients aged 60 years or older diagnosed with hearing loss registered in the CPRD database from January 1, 2001 to December 31, 2020.
• Age groups:
  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Special population of interest:
  Frail population

  Other
• Special population of interest, other:
  Patients with hearing loss
• Estimated number of subjects:
  200

Study design details

• Main study objective:
  Our overarching aim is to assess the association between hearing loss/impairment and fracture risk, and to generate a new short-term (1-year) as well as long-term (10-year) major fracture risk prediction tool for patients with hearing loss that will help clinicians to identify population at high-risk of fracture.
• Outcomes:
  Major osteoporotic fracture: clinical spine, wrist/forearm, shoulder/proximal humerus, and hip fracture, Performance (calibration and discrimination) of major osteoporotic fracture (clinical spine, wrist/forearm, shoulder/proximal humerus or hip fracture) prediction tools for 1- and 10-years
• Data analysis plan:
  Association analysis between hearing loss/impairment and fracture risk: absolute (incidence rate) and relative risk (proportional hazard Cox models) estimates of overall major fractures and of each major fracture subtype associated with hearing loss (hearing loss patients compared to matched unexposed subjects), stratified by age, sex, and high risk of fracture (prior history of fractures, OP diagnosis and/or anti-OP treatment). Risk factors with statistically significant interactions will be evaluated in sub-group analyses. Identification of the risk factors associated with 1- and 10-year major osteoporotic fracture risk amongst patients with hearing loss/impairment, and the consequent model development.

Documents

Study results

20200418 ORSR Abstract