Characteristics and in-hospital outcomes of Chinese elderly (>80 years) patients with acute ischemic stroke receiving intravenous recombinant tissue plasminogen activator treatment within 4.5 hours of symptom onset (0135-0348)

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Other
• Non-interventional study design, other:
  Database analysis

Population studied

• Age groups:
  • Adults (18 to < 46 years)
  • Adults (46 to < 65 years)
  • Adults (65 to < 75 years)
  • Adults (75 to < 85 years)
  • Adults (85 years and over)
• Estimated number of subjects:
  62800

Study design details

• Main study objective:
  • To describe the in-hospital clinical outcomes of AIS patients who were treated with IV rt-PA within 4.5 hours of symptom onset, among those aged 18 to 80 years and >80 years, respectively.
• Outcomes:
  describe the characteristics of AIS patients who arrived or were admitted to the hospital within 4.5 hours of symptom onset and were treated with or without IV rt-PA among different age groups describe the percentage of patients receiving IV rt-PA treatment within 4.5 hours of symptom onset among AIS patients aged 18 to 80 years and above 80 years
• Data analysis plan:
  The primary and secondary outcome will be analysed by using descriptive statistics for group 1 and group 2. The baseline characteristics (covariates) will be analysed by using descriptive statistics for all 4 groups in this study, where group 1 is compared against group 2 and group 1 is compared against group 3. For general statistical considerations, the descriptive statistics for continuous variables will include mean, standard deviation, 95% CI of mean, median, interquartile range, for categorical variables, counts, percentages and 95% CI will be included. For categorical variables, 95% Clopper-Pearson confidence interval will be used.