Aim/s To estimate incidence rates of coagulopathy and thromboembolic events in the general population, in COVID-19 patients, and in recipients of COVID-19 vaccine/s Design We will perform a network cohort study using data mapped to the Observational Medical Outcomes Partnership (OMOP) Common Data Model Population Cohorts: 1) General population, 2) Vaccinated against SARS-CoV-2 with a first dose, 3) Persons vaccinated against SARS-CoV-2 with a second dose, 4) Persons tested positive for SARS-CoV-2, 5) Persons tested positive for SARS-CoV-2 or with a clinical diagnosis of COVID-19, 6) Persons hospitalised with COVID-19, and 7) Persons requiring intensive services during a hospitalisation with COVID-19 Outcomes Venous thromboembolic events, arterial thromboembolic events, rare thrombotic and coagulopathy events, cardiovascular events, and mortality will be identified for all study populations. The occurrence of these events of interest will be identified at 7, 14, 21, and 28 days following vaccination against SARS-CoV-2, while the occurrence of venous thromboembolic and arterial thromboembolic events will be identified in the 30-, 60- and 90-days post-index date for COVID-19 patients. COVID-19 worsening will be defined as increasing care intensity (e.g. from outpatient to inpatient, from inpatient to receiving intensive care services) and/or mortality Data sources Primary care and hospital records from NL (IPCI), IT (IQVIA LPD Italy), FR (IQVIA LPD France), DE (IQVIA DA Germany), ES (SIDIAP and HM), and the UK (CPRD GOLD, CPRD AURUM, and linked HES) Analyses Background rates will be estimated per 100,000 person-years for 2017-2019, at 7, 14, 21, and 28 days following vaccination against SARS-CoV-2, and 30, 60, and 90 days for COVID-19 patients. Rates will be stratified by socio-demographics and cohort. Post-vaccine/background rate ratios will be estimated adjusted for age and sex. Multi-state models will be fitted to study COVID-19 worsening