The prevalence of comorbidities in COPD patients, and their impact on health status and COPD symptoms in primary care patients

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Cross-sectional

Study drug and medical condition

• Medical condition to be studied:
  Chronic obstructive pulmonary disease

Population studied

• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  91600

Study design details

• Main study objective:
  To determine the prevalence of comorbid conditions in COPD patients in primary health care and to assess their association with exacerbation rate and COPD-related health status.
• Outcomes:
  Exacerbations and COPD-related health status measured by the CAT, CCQ or mMRC.
• Data analysis plan:
  Differences between groups (based on number of comorbid conditions) defined as number of exacerbations and COPD-related health status measured by CAT, CCQ or mMRC will be tested using methods such as factorial analysis of covariance (ANCOVA) adjusting for age, sex, FEV1 % of predicted and BMI. Logistic regression will be used for testing the number of comorbidities associated with higher scores of CCQ, CAT and mMRC.