Prevalence of hypereosinophilic syndrome (HES) in the paediatric population in EU (Hypereosinophilic syndrome in children)

Study type

• Study topic:
  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology
• Data collection methods:
  Secondary data collection

Non-interventional study

• Non-interventional study design:
  Other
• Non-interventional study design, other:
  Descriptive study

Study drug and medical condition

• Medical condition to be studied:
  Hypereosinophilic syndrome

Population studied

• Short description of the study population:
  Children 0-11 years of age with possible HES who were identified between January 2010 and June 2021.
• Age groups:
  Term newborn infants (0 – 27 days)

  Infants and toddlers (28 days – 23 months)

  Children (2 to < 12 years)
• Estimated number of subjects:
  500000

Study design details

• Main study objective:
  The objective of this study was to calculate the prevalence of HES in paediatric population.
• Outcomes:
  Hypereosinophilic syndrome
• Data analysis plan:
  Patients were considered observable between their first and their last visit to the practice. Age was calculated for each year during the study period. All children aged 0-11 years with at least one day of observability during the year were included in the yearly prevalence calculation. The age groups 0-5 years and 6-11 years were considered separately. The number of patients with possible HES, and of patients with confirmed HES was provided, cumulatively and per year. Children 0-11 years diagnosed with HES either during the year or earlier were considered to have HES during the year. The number of children that were diagnosed with HES during the year were provided separately. The number of children with HES was expressed as a fraction per million children observed during the year.

Documents

Study results

Updated HES Report - Confidential info edited