Hip fracture information profiling, surveillance and treatment across epidemiological registries (HIPSTAR)

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Medical condition to be studied:
  Hip fracture

Population studied

• Age groups:
  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  1500000

Study design details

• Main study objective:
  The primary objective of this study is to describe the baseline demographic and clinical characteristics of individuals sustaining a hip fracture across a network of real-world databases, including the occurrence of adverse outcomes following surgery.
• Outcomes:
  Bone protection medication at discharge Functional level/mobility at discharge Discharge location Mortality any time point 30 day mortality 90 day mortality Time to surgery Living at home at 3 months Living at home at 90 days Living at home at 30 days Return to pre-fracture residence
• Data analysis plan:
  The study is an observational retrospective cohort study based on routinely-collected health care data which has been mapped to the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). Cohorts of individuals who sustained a hip fracture will be identified using a primary diagnosis that qualifies the individual for entry into the country-level hip fracture registry or dataset. Characteristics of these individuals at their index date will be identified. Treatments and outcomes of these individuals after their index date will be described. Index date is defined in each cohort as either the date of hip fracture procedure or diagnosis depending on their target cohort definition. All analyses will be performed using a common R package, with the code for this study found at https://github.com/BartsBoneJointHealth/HipFractureStudyathon.