DRIVE Brand-specific influenza vaccine effectiveness in Europe, season 2020/21 (DRIVE 2020/21)

Study type

• Study topic:
  Disease /health condition

  Human medicinal product
• Study type:
  Non-interventional study
• Scope of the study:
  Effectiveness study (incl. comparative)
• Data collection methods:
  Combined primary data collection and secondary use of data

Non-interventional study

• Non-interventional study design:
  Case-control

  Cohort

Study drug and medical condition

• Anatomical Therapeutic Chemical (ATC) code:
  (J07BB) Influenza vaccines

  Influenza vaccines
• Medical condition to be studied:
  Influenza

Population studied

• Short description of the study population:
  In all TND studies and the register-based study, the population under study is the general population. In the 2020/21 season, the NIID hospital is dedicated to the treatment of COVID-19, hence, for NIID the study population is the general population with a hospitalized COVID-19 infection.
• Age groups:
  Children (2 to < 12 years)

  Adolescents (12 to < 18 years)

  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Special population of interest:
  Other
• Special population of interest, other:
  Influenza patients
• Estimated number of subjects:
  200000

Study design details

• Main study objective:
  To estimate brand-specific seasonal influenza vaccine effectiveness in Europe by health care setting and age group, influenza season 2020/21.
• Outcomes:
  laboratory confirmed influenza, by type and subtype/lineage
• Data analysis plan:
  Site-specific confounder-adjusted influenza vaccine effectiveness estimates will be obtained using logistic or Poisson regression, depending on the study design. The site-specific estimates will be pooled using random effects meta-analysis.

Documents

Study results

DRIVE_Report_Season-2020-21

Study publications

D7.8 Brand-specific influenza vaccine effectiveness in Europe Season 2020/21 RE…