Optimal dementia risk prediction models and validation for young individuals

Study identification

• EU PAS number:
  EUPAS24833
• Study ID:
  42447
• Official title and acronym:
  Optimal dementia risk prediction models and validation for young individuals
• DARWIN EU® study:
  No
• Study countries:
  France

  United Kingdom
• Study description:
  The objectives of our project are: 1. To conduct a systematic review of statistical methods used for AD pathology risk prediction including previous attempts to create a tool for estimating AD pathology risk score. 2. To estimate risk scores on existing cohorts using a more flexible modeling method than the Cox model. 3. To internally and externally validate the proposed risk prediction model on multiple cohorts 4. To test the prognostic score in the PREVENT cohort of adult volunteers using AD pathology through CSF or PET as endpoints. 5. To use the prognostic score in order to follow the overall risk of AD in PREVENT participants.
• Study status:
  Finalised

Research institutions and networks

Institutions

Inserm Montpellier

Study timelines

Date when funding contract was signed

Planned:15/06/2017

Actual:15/06/2017

Study start date

Planned:10/12/2018

Actual:10/12/2019

Data analysis start date

Planned:04/03/2019

Actual:04/03/2019

Date of interim report, if expected

Planned:07/05/2019

Date of final study report

Planned:31/07/2020

Actual:30/07/2021

Sources of funding

Pharmaceutical company and other private sector 

More details on funding

Merck

Regulatory

• Was the study required by a regulatory body?:
  No
• Is the study required by a Risk Management Plan (RMP)?:
  Not applicable