Study type

Study type

Non-interventional study

Scope of the study

Drug utilisation
Non-interventional study

Non-interventional study design

Cohort
Study drug and medical condition

Anatomical Therapeutic Chemical (ATC) code

(R03D) OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES

Medical condition to be studied

Asthma
Chronic obstructive pulmonary disease
Population studied

Age groups

Children (2 to < 12 years)
Adolescents (12 to < 18 years)
Adults (18 to < 46 years)
Adults (46 to < 65 years)
Adults (65 to < 75 years)
Adults (75 to < 85 years)
Adults (85 years and over)

Estimated number of subjects

1000000
Study design details

Main study objective

By means of a drug utilisation study we want to investigate: • The frequency of respiratory drug use in terms of prevalence and incidence of use • Treatment pathways in particular treatment step-up and treatment step-down • To investigate switching between respiratory drugs • To investigate treatment adherence

Data analysis plan

1/ Drug use will be assessed per respiratory class as a whole presented as prevalent and incident drug use. For prevalent drug use, the nominator consists of all patients with at least one day of exposure to the drug of interest in the calendar year. The denominator consists of all patients contributing at least one day of observation time in that calendar year. For the incidence drug use calculation, the nominator consists of the number of incident users in the year. 2/ This study will describe the treatment pathways of patients diagnosed with asthma, COPD or ACO. The analysis will calculate the aggregate summary statistics for each diagnosis cohort to determine the treatment pathway for each of the respiratory drugs in the study. 3/ Adherence will be assessed using 2 measures of adherence namely the medication possession ratio (MPR) and the proportion days covered (PDC).