Evaluation of potential predictive diagnostic methods for specifity, distribution and relevance of immune checkpoint proteins (EPPIC)

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Drug utilisation

  Effectiveness study (incl. comparative)

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Medical condition to be studied:
  Oesophageal carcinoma

  Gastric cancer

Population studied

• Age groups:
  • Adult and elderly population (≥18 years)

    • Adults (18 to < 65 years)

      • Adults (18 to < 46 years)
      • Adults (46 to < 65 years)
    • Elderly (≥ 65 years)

      • Adults (65 to < 75 years)
      • Adults (75 to < 85 years)
      • Adults (85 years and over)
• Estimated number of subjects:
  2000

Study design details

• Main study objective:
  The main objective of the study is to establish a reliable and robust test method for immune checkpoint expression in cancer tissues to predict therapeutic Response.
• Data analysis plan:
  The data analysis plan includes testing the reliability of immunohistochemical protein expression of cancer tissue considering correlation with expression on gene level and, in correlation to clinical follow up data, potential prediction of therapeutic response.