Study type

Study type

Non-interventional study

Scope of the study

Disease epidemiology
Non-interventional study

Non-interventional study design

Ecological
Study drug and medical condition

Anatomical Therapeutic Chemical (ATC) code

(J07BB) Influenza vaccines
Influenza vaccines

Medical condition to be studied

Acute myocardial infarction

Additional medical condition(s)

Influenza infection
Population studied

Age groups

Adolescents (12 to < 18 years)
Adults (18 to < 46 years)
Adults (46 to < 65 years)
Adults (65 to < 75 years)
Adults (75 to < 85 years)
Adults (85 years and over)

Estimated number of subjects

8240
Study design details

Main study objective

1. To assess the relationship between the incidence of seasonal influenza and incidence of type I AMI,adjusting for ambient temperature.2. To estimate whether the association between the weekly incidence of seasonal influenza and theweekly incidence rate of type I AMI varies by sex and age3. To explore the impact of flu vaccination on the incidence of type I AMI

Outcomes

Type I Acute Myocardial Infarction (AMI)

Data analysis plan

- The incidence rates (IR) of AMI with ST segment elevation (STEMI) in the population older than 14 years old of the Autonomous Community of Madrid (Spain) will be estimated using the registry "Código Infarto". - The association between the weekly incidence of influenza and the incidence rate (IR) of acute myocardial infarction (AMI) in the ACM will be evaluated using an ecological time-series design. Data will be analysed with quasi-Poisson regression models. The shape of the relationship between the weekly incidence of influenza and the IR of AMI will also be studied distributed lag nonlinear models (DLMN).- The impact of flu vaccine on the incidence of AMI will be explored using the status of flu vaccination and the available population statistics of flu vaccination coverage in the region.