Study type

Study type

Non-interventional study

Scope of the study

Effectiveness study (incl. comparative)
Non-interventional study

Non-interventional study design

Cohort
Study drug and medical condition

Medical condition to be studied

Asthma
Population studied

Age groups

Adults (18 to < 46 years)
Adults (46 to < 65 years)
Adults (65 to < 75 years)
Adults (75 to < 85 years)
Adults (85 years and over)

Estimated number of subjects

50000
Study design details

Main study objective

The main objective of the study is to analyze the impact of the asthma review service on asthma exacerbations. This will be achieved by first comparing the number of exacerbations within the review cohort prior to post index, then between the review and control cohort.

Outcomes

The primary objective of the study is to analyze the impact of the asthma review service on asthma exacerbations. This will be achieved by first comparing the number of exacerbations within the review cohort prior to post index, then between the review and control cohort. To compare the number of asthma-related primary care consultations, prescription changes, and hospitalisations in the year prior and post the index date in the review cohort (within-group analysis) and between the review cohort and control cohort (between-group analysis).

Data analysis plan

This study will use a cluster matched strategy in which each practice in the review cohort will be matched to a practice in the control cohort. Multivariable mixed effects Poisson regression models will be used to analyze the change in asthma exacerbations within and between the review and control groups. For the within-group analysis, the follow-up indicator variable will be used to determine if the rate of exacerbations changed from baseline to follow-up for the review group. Incidence rate ratios (IRRs), 95% confidence intervals and p-values will be reported.