Study type

Study type

Non-interventional study

Scope of the study

Drug utilisation
Non-interventional study

Non-interventional study design

Cohort
Study drug and medical condition

Anatomical Therapeutic Chemical (ATC) code

(M01C) SPECIFIC ANTIRHEUMATIC AGENTS
SPECIFIC ANTIRHEUMATIC AGENTS

Medical condition to be studied

Rheumatoid arthritis
Population studied

Age groups

  • Adult and elderly population (≥18 years)
    • Adults (18 to < 65 years)
      • Adults (18 to < 46 years)
      • Adults (46 to < 65 years)
    • Elderly (≥ 65 years)
      • Adults (65 to < 75 years)
      • Adults (75 to < 85 years)
      • Adults (85 years and over)

Estimated number of subjects

300000
Study design details

Main study objective

The main objectives of this study are to investigate:- the type of first DMARD being prescribed (first year and first 5 years)- utilisation of second line DMARDs (first year and first 5 years)- proportion of patients not being treated with first line DMARDs - characterize use of DMARDs over calendar time

Data analysis plan

This study will describe the treatment pathways of patients diagnosed with RA. The analysis will calculate the aggregate summary statistics for each RA cohort to determine the treatment pathway for each of the DMARDs in the study For each of the cohorts, a sunburst diagram will be produced to describe the proportion of DMARD treatments for each treatment sequence observed in the target population. The sunburst diagram will have a maximum of 10 levels. The incidence and prevalence of RA will be calculated for each database in the study and expressed as number of new patients diagnosed with RA/1,000 individuals (for incident) or the number of patients with RA (prevalent)/1,000 individuals. This will be done by year, stratified by age and gender. Descriptive statistics will be used (absolute count, proportion, mean & median)