Study type

Study type

Non-interventional study

Scope of the study

Disease epidemiology
Non-interventional study

Non-interventional study design

Cross-sectional
Study drug and medical condition

Medical condition to be studied

Asthma
Population studied

Age groups

Adults (18 to < 46 years)
Adults (46 to < 65 years)
Adults (65 to < 75 years)

Estimated number of subjects

5000
Study design details

Main study objective

To describe and compare the demographic and clinical features of eosinophilic and non-eosinophilic asthma phenotypes in a cohort of adult patients with severe asthmaTo investigate the unique clusters of asthma phenotypes in the international severe asthma registry

Outcomes

Description and comparison of demographic and clinical features of the eosinophilic versus non-eosinophilic phenotypes of severe asthma, Unique clusters of severe asthma phenotypes in the international severe asthma registry (ISAR)

Data analysis plan

Firstly, most likely non-eosinophilic asthma patients will be identified followed by discerning eosinophilic asthma patients with most likely vs likely degree of confidence. Descriptive statistics will be provided for continuous and categorical variables accordingly. Summary statistics will be produced for variables measured on the interval or ratio scale, including sample size, mean and SD and categorical variables including range and the percentage by category. A benchmark for each descriptive statistic will be calculated using OPCRD data. Characteristics of groups will be compared via contingency tables and group difference will be tested for statistical significance. Data reduction methods will be used to validate the expected clusters of eosinophilic phenotype and/or to investigate the unique cluster present in the ISAR cohort. Univariate distributions for patient characteristics and clinical characteristics will be described for four identified phenotypes.