Biologics in severe asthma: utilization patterns, causes for discontinuation and switches

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

  Drug utilisation

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Medical condition to be studied:
  Asthma

Population studied

• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  5000

Study design details

• Main study objective:
  To describe the use of biologics in patients with severe asthma, with respect to persistence and switch to another biologic, and how this relates to asthma outcomes
• Outcomes:
  To describe the frequency, patterns, reasons and clinical outcomes for biologic treatment discontinuation and switching in a severe asthma cohort. To describe the demographical and clinical characteristics of severe asthma patients that discontinue or switch their biologic therapy, stratified by country.
• Data analysis plan:
  Stata version 14.2 SE and 15.1 MP/6 (College Station, TX, USA) will be used to conduct allstatistical analyses and data manipulations. All descriptive statistics will be done with datathat is not missing. For each variable with missing values, the percentage of missingness will be reported.