SEROLOGICAL EVOLUTION OF PRIMARY INFECTION BY EPSTEIN-BARR VIRUS IN CHILDREN

Study type

• Study topic:
  Other
• Study topic, other:
  Epidemiological, clinical and laboratory characteristics
• Study type:
  Non-interventional study
• Scope of the study:
  Assessment of risk minimisation measure implementation or effectiveness

  Disease epidemiology
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Other
• Non-interventional study design, other:
  Case-series

Population studied

• Short description of the study population:
  Patients with positive or indeterminate results of the Epstein-Barr virus (EBV)-VCA IgM test over a period of 22 months
• Age groups:
  • Children (2 to < 12 years)
  • Adolescents (12 to < 18 years)
• Estimated number of subjects:
  94

Study design details

• Main study objective:
  To describe serological evolution of primary infection by EBV in immunocompetent children and calculated the probability of not create EBNA antibodies
• Outcomes:
  The probability of not create EBNA antibodies was 48% at 6 months, 25% at 1 year and 10% at 2 years after primary infection. Only a few patients didn´t have humoral response with EBNA antibodies or created them lately. Anyone of them had symptoms of chronic active EBV infection. Female sex associated with a delay in disappear VCA IgM antibodies and in create EBNA antibodies.
• Data analysis plan:
  We used a Poisson regression variation to determine the influence of variables in time until seroconversión. The statistical model considered the losts of patients along the study.