Study type

Study type

Non-interventional study

Scope of the study

Assessment of risk minimisation measure implementation or effectiveness
Disease epidemiology
Non-interventional study

Non-interventional study design

Cross-sectional
Study drug and medical condition

Medical condition to be studied

Asthma
Population studied

Age groups

Adolescents (12 to < 18 years)
Adults (18 to < 46 years)
Adults (46 to < 65 years)
Adults (65 to < 75 years)
Adults (75 to < 85 years)
Adults (85 years and over)

Estimated number of subjects

400000
Study design details

Main study objective

To describe and compare characteristics, such as asthma severity and control and health care resource utilisation (HCRU) of patients with predefined grades of likelihood of the eosinophilic asthma phenotype in a recent population of real-life patients with active asthma and to compare these phenotypes with phenotypes identified from unsupervised cluster analyses

Data analysis plan

Demographics, diagnosed comorbidities, clinical characteristics, such as asthma severity and control and HCRU of asthma patients will be described for the total population and for different phenotypes separately.Analyses will be repeated in the subpopulation of patients who were on the register of patients with active asthma that general practitioners maintain in the UK within the Quality and Outcomes Framework (QOF). Within this subpopulation characteristics will be also be compared between patients with and without severe asthma (as questionnaire data will be available for more detailed assessment of asthma control).K-means clustering will be used to identify clusters of eosinophilic phenotypes using all available characteristics.Patient groups distinguished based on the longitudinal pattern of eosinophil counts will be characterised and compared in a baseline period prior to the last eosinophil count and future clinical outcomes & HCRU will be compared in a follow-up year.