Impact of obstructive sleep apnea diagnosis on healthcare resource utilization in patients with obstructive lung disease

Study type

• Study topic:
  Disease /health condition

  Other
• Study topic, other:
  Healthcare resource utilization
• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

  Healthcare resource utilisation
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

  Cross-sectional

Study drug and medical condition

• Medical condition to be studied:
  Sleep apnoea syndrome

Population studied

• Short description of the study population:
  Patients with sleep-related breathing disorder (SBD, including obstructive sleep apnoea).; ; Patients with following criteria were included:; 1. ≥18 years of age; 2. A physician diagnosis of SDB, defined as ≥1 SBD diagnostic codes; ; Additional criteria for Aim 3; - Three years of continuous data: ≥1 year prior to the first recorded SDB code (“index date”) and ≥2 years immediately after index date.; - An active Obstructive Lung Disease (OLD):; o Asthma subpopulation: a Quality Outcomes Framework (QoF) Read code for asthma ever prior to index date, ≥2 asthma prescriptions in each of the baseline years; no COPD Read code in the 4-year study period; o COPD subpopulation: a QoF Read code for COPD prior to index date, ≥2 COPD prescriptions in each of the baseline years; no asthma Read code in the 4-year study period
• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Special population of interest:
  Other
• Special population of interest, other:
  Sleep-related Breathing Disorders patients
• Estimated number of subjects:
  8500

Study design details

• Main study objective:
  To evaluate the impact of (i) CPAP and (ii) a SBD diagnosis and (iii) an OSA diagnosis on clinical outcomes and healthcare resource utilization in a representative SBD population of patients in the United Kingdom with comorbid obstructive lung disease.
• Outcomes:
  Acute respiratory event ratei) Hospital admissionsii)A&E attendanceiii)Acute course of oral steriodsiv) Antibiotic prescriptions, Overall healthcare cost-Total: Encounter + Drug related.
• Data analysis plan:
  Outcome comparison between pre- and post index date periods, for:i) All Active Patientsii) All Active OLD sub-populations (asthma, COPD, asthma & COPD)