HPV vaccines effectiveness to prevent genital warts in Valencia Region, Spain

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Effectiveness study (incl. comparative)

Non-interventional study

• Non-interventional study design:
  Cohort

  Other
• Non-interventional study design, other:
  Population-based study

Study drug and medical condition

• Medical condition to be studied:
  Papilloma viral infection

Population studied

• Age groups:
  • Paediatric Population (< 18 years)

    • Adolescents (12 to < 18 years)
  • Adult and elderly population (≥18 years)

    • Adults (18 to < 65 years)

      • Adults (18 to < 46 years)
      • Adults (46 to < 65 years)
• Estimated number of subjects:
  3300000

Study design details

• Main study objective:
  To estimate the effectiveness of the HPV vaccines to prevent genital warts in women aged from 14 to 23+ years old (depending on the date of data extraction).
• Outcomes:
  Incident cases of Genital Warts in primary care and outpatient clinics. Precancerous lesions
• Data analysis plan:
  Crude and adjusted VE overall and in IC population for bivalent and quadrivalent vaccines and the risk of GW in IC subjects respect to IC-free will be estimated by statistical models considering time-dependent variables. Variables that are relevant to the disease or can impact on the incidence of genital warts will be considered.