Case-control study based on hospitals about seasonal influenza vaccine effectiveness to avoid income associated with laboratory-confirmed influenza virus infection in subjects aged 18 or more during 2011-2020 seasons and the disease burden due to respiratory viruses in patients of any age admitted into the hospitals included in the study (AIV - Fisabio) (HBTNCC)

Study type

• Study type:
  Non-interventional study

Non-interventional study

• Scope of the study:
  Disease epidemiology

  Effectiveness study (incl. comparative)
• Non-interventional study design:
  Case-control

Study drug and medical condition

• Medical condition to be studied:
  Influenza

  Influenza like illness

Population studied

• Age groups:
  Preterm newborn infants (0 – 27 days)

  Term newborn infants (0 – 27 days)

  Infants and toddlers (28 days – 23 months)

  Children (2 to < 12 years)

  Adolescents (12 to < 18 years)

  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Special population of interest:
  Renal impaired

  Hepatic impaired

  Immunocompromised

  Pregnant women
• Estimated number of subjects:
  12000

Study design details

• Main study objective:
  To measure seasonal influenza vaccine efectiveness to avoid laboratory-confirmed entries in adults 18 years of age or older.To measure disease burden due to respirartory viruses in patients of all ages.
• Data analysis plan:
  Study of hospital-based cases and controls and active epidemiological surveillance of income related to respiratory viruses.