Prevalence of COPD patients with signs of asthma according to Dutch GP guidelines

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Cross-sectional

Study drug and medical condition

• Medical condition to be studied:
  Chronic obstructive pulmonary disease

  Asthma-chronic obstructive pulmonary disease overlap syndrome

Population studied

• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  4900

Study design details

• Main study objective:
  To describe the prevalence of asthma characteristics in patients with pulmonologists working diagnosis of Chronic Obstructive Pulmonary Disease or Asthma/COPD overlap.
• Outcomes:
  The primary outcome is the percentage of COPD/ACO patients with asthma characteristics including history of asthma, symptom pattern, history of atopy, reversibility. Additionally, the percentage of COPD/ACO patients which have one, two and three or more asthma characteristics are examined. The percentage of COPD and ACO patients with an exacerbation in the last year and the percentage of COPD and ACO patients with positive respiratory IgE levels. Additionally, the percentage of asthma characteristics in COPD/ACO patients who have a blood eosinophil count of ≤150 cells per µL, between 150-300 cells per µL or ≥300 per µL.
• Data analysis plan:
  Standard statistical techniques and methodologies will be used to present the results of the intended goals described earlier, using SPSS, version 25.Baseline characteristics will be shown as mean ± standard deviation (SD) or, in case of non-normally distributed data, median and interquartile range (IQR). The proportions of the asthma characteristics will be depicted in percentages.