Epidemiological trends of Alpha1-antitrypsin deficiency (AATD) in the UK: prevalence and incidence from 1990 to 2015

Study type

• Study topic:
  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Medical condition to be studied:
  Alpha-1 anti-trypsin abnormal

Population studied

• Short description of the study population:
  Individuals who were diagnosed with Chronic obstructive pulmonary disease (COPD) before the age of 60 years, and have been tested for Alpha1-antitrypsin deficiency (AATD) (i.e. Read code for AATD) between 1990 and 2015.
• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)
• Special population of interest:
  Other
• Special population of interest, other:
  Chronic obstructive pulmonary disease (COPD) patients
• Estimated number of subjects:
  600

Study design details

• Main study objective:
  Pilot study to determine the epidemiological pattern and characteristics of AATD in COPD patients in the UK population.Specifically-1) Prevalence and incidence of AATD, in all and by age and gender. 2) Determine the demographic and clinical characteristics associated with AATD.
• Outcomes:
  Frequency of testing, prevalence and incidence of AATD
• Data analysis plan:
  This will be an exploratory and descriptive study.Summary statistics will be produced for prevalence and incidence of AATD, by all covariates. The number of patients/observations and percentage per category, mean plus standard deviation and median plus inter-quantile range will be given, as appropriate.Statistical tests (e.g. F-tests, t-tests, chi-squared tests) and models (e.g. linear models) will be used, as appropriate.Statistically significant results will be defined as p<0.05.