Use of thiazides and risk of skin cancer - systematic review and meta-analysis (Thiazides and skin cancer)

Study type

• Study topic:
  Human medicinal product

  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Assessment of risk minimisation measure implementation or effectiveness
• Data collection methods:
  Secondary data collection

Non-interventional study

• Non-interventional study design:
  Systematic review and meta-analysis

Study drug and medical condition

• Anatomical Therapeutic Chemical (ATC) code:
  (C03AA) Thiazides, plain
• Medical condition to be studied:
  Skin cancer

  Skin cancer metastatic

Population studied

• Short description of the study population:
  Subjects with non-melanoma skin cancer (NMSC) and malignant melanoma (MM) identified from the interventional and non-interventional studies received treatment with any thiazide diuretic, single or in combination, at class level or substance level.
• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Special population of interest:
  Other
• Special population of interest, other:
  Malignant melanoma patients
• Estimated number of subjects:
  100000

Study design details

• Main study objective:
  To quantify the association between the use of thiazides drugs and the risk of skin cancer
• Outcomes:
  Skin cancer
• Data analysis plan:
  A search in Medline and Embase was conducted in order to identify interventional and non-interventional studies that investigated the association between thiazides and NMSC or MM in any population

Documents

Study publications

Morales DR, Pacurariu A, Slattery J, Kurz X. Association between hydrochlorothi…